Affiliation:
1. Zaporizhzhia State Medical University
2. Enamine Ltd
Abstract
Objective: The aim of the work was to develop effective methods for the synthesis of promising condensed heterocyclic systems based on pyrazole and 1,2,4-triazole. In the process of realizing the set goal, a number of new pyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazines were synthesized.
Material and Method: Chemical structures of synthesized compounds were characterized with elemental analysis, 1H-NMR, LC-MS techniques. The biological potential of the synthesized substances was estimated by the molecular docking method.
Result and Discussion: An optimal method for the synthesis of pyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazines has been developed. In molecular modeling studies, the compounds were found to be similar to known drugs in some respects. The interaction of each molecule with the crystal structures of cyclooxygenase-2, lanosterol-14α-demethylase, kinases of anaplastic lymphoma in the active site were considered as in silico.
Publisher
Ankara Universitesi Eczacilik Fakultesi Dergisi
Subject
Pharmaceutical Science,Pharmacology
Reference26 articles.
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