S-ALKİL 4-(4-KLOROFENİL)-5-(PİROL-2-İL)-1,2,4-TRİAZOL-3-TİYOL TÜREVLERİNİN SENTEZİ VE ÖZELLİKLERİ
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Published:2023-09-04
Issue:3
Volume:47
Page:32-32
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ISSN:1015-3918
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Container-title:Ankara Universitesi Eczacilik Fakultesi Dergisi
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language:en
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Short-container-title:Ankara Ecz. Fak. Derg.
Author:
GOTSULYA Andrey1ORCID, FEDOTOV Serhii2ORCID, ZINYCH Olena2ORCID, TROFIMOVA Tetiana3ORCID, BRYTANOVA Tetiana2ORCID
Affiliation:
1. Zaporizhzhia State Medical and Phamaceutical University 2. Zaporizhzhia State Medical and Pharmaceutical University 3. Bogomolets National Medical University
Abstract
Objective: The aim of the work was to develop effective methods for the synthesis of promising heterocyclic systems based on pyrrole and 1,2,4-triazole. In the process of realizing of this aim, 10 new S-alkyl 4-(4-chlorophenyl)-5-(pyrrole-2-yl)-1,2,4-triazole-3-thiol derivatives were synthesized.
Material and Method: Chemical structures of synthesized compounds were characterized with elemental analysis, 1H-NMR, LC-MS techniques. The biological potential of the synthesized substances was estimated by the molecular docking method and ADME analysis.
Result and Discussion: An optimum method for the synthesis of S-alkyl 4-(4-chlorophenyl)-5-(pyrrole-2-yl)-1,2,4-triazole-3-thiol has been developed. In molecular modeling studies, the compounds were found to be similar to known drugs in some respects. The interaction of each molecule with the crystal structures of cyclooxygenase-2, lanosterol-14α-demethylase in the active site was considered in silico. Pharmacokinetic parameters for a number of the synthesized compounds have been predicted by ADME analysis.
Publisher
Ankara Universitesi Eczacilik Fakultesi Dergisi
Subject
Pharmaceutical Science,Pharmacology
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