Liver retransplantation in the modern concept of treatment of its terminal pathology (literature review)

Author:

Akhmedov A. R.1ORCID,Novruzbekov M. S.2ORCID,Gulyaev V. A.1ORCID,Olisov O. D.1ORCID,Lutsyk K. N.1ORCID,Magomedov K. M.1ORCID,Kazymov B. I.3ORCID,Alekberov K. F.1ORCID,Anosova E. Yu.1ORCID,Yaremin B. I.4ORCID

Affiliation:

1. N.V. Sklifosovsky Research Institute of Emergency Medicine

2. N.V. Sklifosovsky Research Institute of Emergency Medicine; N.I. Pirogov Russian National Research Medical University

3. N.V. Sklifosovsky Research Institute of Emergency Medicine; Moscow Medical University "Reaviz"

4. N.V. Sklifosovsky Research Institute of Emergency Medicine; N.I. Pirogov Russian National Research Medical University; Moscow Medical University "Reaviz"

Abstract

The work is devoted to the analysis of modern literature data and approaches in performing repeated liver transplantation. The most frequent causes of liver graft loss are PNFT, HAT, recurrent initial disease and chronic rejection. The leading indication for retransplantation in children is HAT. The one-year survival rate after retransplantation is approximately 75%. Reducing the cost of organ retransplantation and the cost-effectiveness of the procedure are controversial issues. Mathematical modeling has identified several significant recipient and donor factors affecting the outcomes of retransplantation. Despite ethical and economic considerations, retransplantation is the only option for transplant patients whose grafts have failed to engraft. The decision to retransplant should be made with some caution, with full multi-type approach in large multidisciplinary transplant centers.

Publisher

Reaviz Medical University

Subject

General Engineering

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