The role of immune mechanisms in kidney damage in hemorrhagic fever with renal syndrome-Reference-Cited by-同舟云学术

The role of immune mechanisms in kidney damage in hemorrhagic fever with renal syndrome

Published:2023-05-30 Issue:3 Volume:13 Page:93-98
ISSN:2782-1579
Container-title:Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH)
language:
Short-container-title:vmirvz

Author:

Ivanov M. F.¹^ORCID,Konstantinov D. Yu.¹^ORCID,Balmasova I. P.²^ORCID,Ulitina A. Yu.¹^ORCID

Affiliation:

1. Samara State Medical University

2. A.I. Evdokimov Moscow State University of Medcine & Dentistry

Abstract

The study is devoted to the assessment of the role of immune mechanisms in the development of acute renal failure in HFRS. The material for the study was the blood of 65 patients with HFRS and 17 patients with ALF of toxic nature from the comparison group as models of kidney damage by hantavirus and non-infectious genesis and 15 clinically healthy subjects of the control group. Data were obtained that allow us to consider the cytolytic effects of natural killer cells and cytotoxic T-lymphocytes activated by the NKG2D-dependent method as damage factors, including renal tissue, and a significant increase in the content of regulatory T-cells in the blood as protective mechanisms.

Publisher

Reaviz Medical University

Subject

General Medicine

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