Morphological changes of tissues after the implantation of the biodegradable threads for the correction of the involution of the hand’s back side skin

Abstract

The aging process of the skin of the hand continuously progresses from mature to advanced age. With age, the skin of the hand becomes pigmented, dry, wrinkled with an emphasized skin pattern, the tone of the skin of the hand decreases, thinning and atrophy of adipose tissue are noted, skin elasticity is lost with the formation of an excess of hypoelastic thinned dermis. In recent years, smooth thread implants have been used to correct involutional changes in the skin of the back of the hand. The aim of the study was a morphological evaluation of the effectiveness of the correction of involutional changes in the skin of the back surface of the hand with thread implants based on polycaprolactone and poly-L-lactic acid (PCL-PLLA) with notches. Using light and electron microscopy, we studied the reaction of cells and intercellular substance to the introduction of biodegradable filaments into the subcutaneous space. It was found that implantation of PCL-PLLA filaments increases the reparative potential of tissues. 3 months after implantation, stimulation of neocollagenesis and angiogenesis in the dermis and hypodermis was noted. The functional and proliferative activity of cells increased. Mitotic activity of cells in the basal layer of the epidermis led to an increase in its thickness. A clinically confirmed effect was noted after 3 months and persisted for 18 months after implantation. Long biodegradation of the threads (1.5-2 years) helps to slow down the aging process of the skin of the back surface of the hand, prolonging the processes of tissue revitalization.