THE INFLUENCE OF THE BONE MARROW XENOTRANSPLANTATION ON PRODUCING OF MEDIATORS BY ITS NEUROAMINE-PRODUCING CELLS

Abstract

The quantitative indicators of neuroamine-producing cells and the content of neuromediators in them were analyzed, the correlation of indicators of their production after bone marrow xenotransplantation was studied. The experiments were conducted on white laboratory mice, which were injected with a cell suspension obtained from a domestic cats into the tail vein. In the early stages of the experiment, the number of neuroamine-producing cells increases, with an increase in the content of neurotransmitters in them. In the subsequent periods of the experiment, their number decreases and the production of all neuromediators (catecholamines, serotonin, histamine) sharply decrease. The formation of lipocytes in the transplanted tissue is showed. Correlations between the levels of neuromediators in neuroamine-producing bone marrow cells also change. Thus, bone marrow xenotransplantation leads to a decrease in the number and production of neuromediators by neuroamine-producing cells within two days.