Neurospecific markers of brain damage in infants

Abstract

Timely diagnosis of brain lesions in infants is important for preventing the development and progression of neurological diseases.Purpose. The study aimed at investigation of neurospecific laboratory parameters in children of 1 year of age with structural changes in the brain.Material and methods. The clinical and laboratory examination of 50 children of 1 year of age, born at full term, was carried out. Serum concentrations of neurotrophic growth factor (BDNF), fractalkine (CX3CL-1), monocytic chemotactic protein (CCL2), trigger receptor expressed on myeloid cells-1, 2 (TREM-1, TREM-2), transforming growth factor-ȕ1 (TGF-ȕ1), nerve growth factor-ȕ (ȕ-NGF), visinin-like protein-1 (VILIP-1), vascular endothelial growth factor (VEGF), glycosylation end product receptor (sRAGE), interleukin (IL)-6, IL-18, and tumor necrosis factor Į (TNF-Į).Results. Predictors of brain damage in full-term infants have been identified. The level of TGFB-1 in children with structural changes in the brain exceeded that of the control group by 1.4 [1.1; 1.6] times, the level of AntiGRIN2A — 1.6 [1.1; 2.0] times, which makes it possible to consider these parameters as biomarkers of brain damage.Conclusion. Based on the results obtained, an additional laboratory examination of children who have undergone ante- and intranatal hypoxia is recommended, including the determination of the level of neurodamage biomarkers such as: TGFB-1 and AntiGRIN2A. This study will contribute to the timely detection of disorders of the central nervous system and the initiation of therapy to prevent the development and progression of neurological pathology in childhood.