Affiliation:
1. Pirogov Russian National Research Medical University.
Abstract
Bronchiectasis is characterized by a chronic and abnormal expansion of the respiratory tract; it is caused by impaired clearance of various microorganisms and recurrent infection. The cause of 26%–53% cases of bronchiectasis is unknown, which means that their etiology and pathogenesis are to be studied. This review summarizes current knowledge of epidemiology, pathophysiology, clinical features and management of children with bronchoectatic disease. Recent data allow us to improve our understanding of this heterogeneous disease, for example, the role of the interaction of the immune system and microbiota in the pathogenesis of bronchoectatic disease.
Publisher
The National Academy of Pediatric Science and Innovation
Subject
Pediatrics, Perinatology and Child Health
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