Affiliation:
1. Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
2. Russian Clinical and Research Center of Gerontology of the Pirogov Russian National Research Medical University
Abstract
Genetic aspects regulate the intensity and rate of aging (no toxic effects considered), their negative role depends on the pathogenicity of the mutation. The light variant of the genetic “defect” has no clinical signs which feature a certain known genetic syndrome, but it has the biochemical, immunological, vascular and other abnormalities leading to pathological aging. In the most severe case, e.g. progeria, pathological aging is the main phenotypic symptom that manifests already in childhood. The subject of the pathological aging research covers the whole range of intermediate states. The review focuses on aging in individuals without validated signs of disease: coronary heart disease, hypertension, diabetes or fasting hyperglycemia, hyperlipidemia, and others. The authors present the main searching directions of aging biomarkers (size and speed of telomere shortening, breaks in their terminal loops; expression of inflammatory proteins, synaptic interactions proteins and neurotrophic processes; mitochondrial biogenesis; endothelial dysfunction; DNA methylation activity).
Publisher
The National Academy of Pediatric Science and Innovation
Subject
Pediatrics, Perinatology and Child Health
Reference35 articles.
1. Wang C., Oshima M., Sashida G., Tomioka T., Hasegawa N., Mochizuki-Kashio M. et al. Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice. PLoS One 2015; 10(7): e0132041. DOI: 10.1371/journal.pone.0132041
2. Kruglikova A.S., Strajesko I.D., Tkacheva O.N., Akasheva D.U., Plokhova E.V., Pykhtina V.S. et al. Interrelation between cardiovascular risk factors and telomere biology with the signs of vascular aging. Kardiovaskulyarnaya terapiya i profilaktika (Cardiovascular Therapy and Prevention) 2014; 13(3): 11–17. (in Russ.).
3. Vasylenko N.Yu. Social gerontology. Vladivostok: Publishing house of the Far East University 2003; 140. (in Russ.).
4. Gichev Yu.P. Environmental conditionality of premature growth and shortening of the life expectancy of the population of Russia. Gigiyena i sanitariya (Hygiene and sanitation) 2002; 6: 48–51. (in Russ.).
5. Todorov I.N., Todorov G.I. Stress, aging and their biochemical correction. Moscow: Nauka, 2003; 479. (in Russ.).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献