Affiliation:
1. Belarusian State Medical University
2. Clinical Maternity Hospital of the Minsk Region
3. Belarusian State Medical University; Clinical Maternity Hospital of the Minsk Region
4. Research and Production Unitary Enterprise «Belreamed»
Abstract
Currently, significant progress has been made in the prevention, diagnosis and treatment of hemolytic disease of the fetus and newborn. However, the development of anemia in a newborn child due to this disease remains an urgent problem for both neonatologists and pediatricians. In such children, a comprehensive assessment of the hemogram is of particular importance. The study of erythrocyte and reticulocyte parameters of a general blood test is necessary to determine prognostic criteria for the restoration of hematopoiesis and determine the status of iron deficiency. A clinical observation of a newborn child with the development of anemia due to hemolytic disease of the fetus and newborn is presented (clinical case). A dynamic analysis of reticulocyte parameters (absolute and relative numbers) and reticulocyte fractions was carried out. An increase in reticulocytes (absolute and relative numbers) was established, mainly due to the fraction of immature reticulocytes during the development of anemia in a newborn child. Such indicators as the hemoglobin content in reticulocytes, the average hemoglobin content in an erythrocyte, the average hemoglobin concentration in an erythrocyte in a general blood test in an infant during the neonatal period remained within the reference values. The data obtained made it possible to determine a personalized approach to the treatment of anemia and avoid blood transfusion in this child.
Publisher
The National Academy of Pediatric Science and Innovation
Reference9 articles.
1. Sheibak L.N. Modern concept of hemolytic disease features of the fetus and newborn. Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta 2015; 1: 134–135. (in Russ.)
2. Antonov A.G., Degtyarev D.N., Narogan M.V., Karpova A.L., Senkevich O.A., Sapharov A.A. et al. Hemolytic disease of the fetus and newborn. Clinical guidelines. Neonatologiya: novosti, mneniya, obuchenie 2018; 6(2): 131–142. (in Russ.)
3. al-Alaiyan S., al Omran A. Late hyporegenerative anemia in neonates with rhesus hemolytic disease. J Perinat Med 1999; 27(2): 112–115. DOI: 10.1515/JPM.1999.014
4. Zakharova I.N., Tarasova I.S., Chernov V.M., Machneva E.B., Vasilyeva T.M. Reticulocyte indices in diagnosis and control of effectiveness of treatment of iron deficiency conditions in children. Pediatricheskaya farmakologiya 2015; 12(6): 692–696. (in Russ.) DOI: 10.15690/pf.v12i6.1494
5. Auerbach M., Staffa S.J., Brugnara C. Using Reticulocyte Hemoglobin Equivalent as a Marker for Iron Deficiency and Responsiveness to Iron Therapy. Mayo Clin Proc 2021; 96(6): 1510–1519. DOI: 10.1016/j.mayocp.2020.10.042