Affiliation:
1. Astrakhan State Medical University
2. Sechenov First Moscow State Medical University (Sechenov University)
Abstract
The intercellular matrix in bronchial asthma is involved in both reversible and irreversible processes of structural change. Markers of endothelial disorders, indicators of extracellular matrix structures may have diagnostic significance.Purpose. To study the clinical significance of markers of collagen genesis and plasma endothelin-1 in bronchial asthma in children, depending on the severity and duration of the disease.Material and methods. 268 patients aged from 2 years 11 months to 17 years 11 months with an established diagnosis of bronchial asthma with varying degrees of severity were examined. The ELISA method determined the serum levels of the following indicators: antibodies to type I and type III collagen, plasma endothelin.Results. There was a significantly significant increase in fibroblast growth factor, type I collagen antibodies in children with severe bronchial asthma.Conclusion. These indicators are a diagnostic marker for a severe bronchial asthma.
Publisher
The National Academy of Pediatric Science and Innovation
Subject
Pediatrics, Perinatology and Child Health
Reference28 articles.
1. Be'j-Dzhensen A., I Dzh. M.B., Dzhenoveze F., Zibur A.S., Nil'sen M., Liming D.Dzh. Biochemistry of collagens, laminins and elastin, Academic Press, 2016; 203–233. (in Russ.)
2. Robert J., Dhiren F., Patel F. Zooming into the Matrix: Using Nonlinear Optical Microscopy to Visualize Collagen Remodeling in Asthmatic Airways Am J Respir Crit Care Med 2019; 200(4): 403–405. DOI: 10.1164/rccm.201904–0722ED
3. Burgess J., Mauad T., Tjin G., Karlsson J., Westergren-Thorsson G. The extracellular matrix–The under-recognized element in lung disease? J Pathol 2016; 240: 397–409. DOI: 10.1002/path.4808
4. Halfter W., Oertle P., Monnier C., Camenzind L., Reyes-Lua M., Hu H. et al. New concepts in basement membrane biology. FEBS 2015; 282: 4466–4479. DOI: 10.1111/febs.13495
5. Le B., Macdonald B., Kalluri R. Structure and Function of Basement Membranes. Exp Biol Med 2007; 232: 1121–1129. DOI: 10.3181/0703-MR-72