Affiliation:
1. Sechenov First Moscow State Medical University (Sechenov University)
2. Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University
Abstract
Currently, there is no unified system of anti-relapse treatment of pyelonephritis in children.Purpose. To assess the feasibility of prescribing and effectiveness of various anti-relapse therapy regimens to prevent exacerbations of the disease in children with chronic secondary pyelonephritis.Materials and Methods. The study involved 158 children with chronic secondary pyelonephritis aged 2 to 14 years, including 130 (82.3%) girls and 28 boys (17.7%). The children were divided into the following groups: Group A (n=32) — furazidine — 14 days, anti-relapse therapy after 12 months; Group B (n=34) — furazidine — 14 days, then — Canephron 1 month, anti–relapse therapy after 12 months; Group C (n=34) — Canephron 3 months, anti-relapse therapy after 12 months; Group D (n=30) — furazidine — 14 days, then — Canephron 1 month of anti–relapse therapy after 6 months; Group E (n=28) — furazidine — 14 days of anti-relapse therapy was not performed. Results. It was found that the recurrence rate of chronic secondary pyelonephritis for a 24-month follow-up in Group A was 28.1% (n=9), in Group B, 14.7% (n=5), in Group C, 20.5% (n=7), in Group D, 10% (n=3), in Group E, 42.9% (n=12). The timing of relapse of chronic secondary pyelonephritis was different, with the largest increase in the proportion of patients with exacerbations in the period from 6 to 12 months. The average recurrence rate per year in the catamnesis in all children (n=158) was 1.4 [1.2–1.6], during the prospective follow-up, a statistically significant (p=0.001) decrease in the recurrence rate to 0.36 [0.2–0.79] was noted. Conclusion. The data obtained confirm the feasibility of anti-relapse therapy in children with chronic secondary pyelonephritis.
Publisher
The National Academy of Pediatric Science and Innovation
Subject
Pediatrics, Perinatology and Child Health