Dynamics of the cytokine profile in achieving the therapeutic effect of allergen-specific immunotherapy in children with allergic rhinitis and bronchial asthma

Abstract

Allergen-specific immunotherapy is a pathogenetic method for the treatment of IgE-mediated allergic diseases.Objective. To evaluate effectiveness of allergen-specific immunotherapy in 471 children with allergic rhinitis and bronchial asthma, as well to analyze the dynamics of the cytokine profile at baseline and 1 year after the start of treatment in 86 children. The research was supported by a grant from the International Scientific Council for Young Scientists of Kazan State Medical University.Results. Analysis of the data obtained demonstrated that allergen-specific immunotherapy is a highly effective method of treating children with allergic rhinitis and atopic bronchial asthma. The dynamics of the level of the studied cytokines during treatment indirectly indicates an increase in the functional activity of adaptive subpopulations of regulatory T-lymphocytes (T-reg) and B-lymphocytes (B-reg) with a decrease in the activity of Th2 lymphocytes, which may indicate the reconstruction of the immune response and possible disease-modifying effect.