Affiliation:
1. Sechenov First Moscow State Medical University (Sechenov University); Speransky Children’s Municipal Clinical Hospital No.9
2. Sechenov First Moscow State Medical University (Sechenov University)
3. Sechenov First Moscow State Medical University (Sechenov University); Speransky Children’s Municipal Clinical Hospital No.9; Veltischev Research and Clinical Institute for Pediatrics at the Pirogov Russian National Research Medical University
Abstract
A-type botulinum toxin blocks presynaptic production of acetylcholine, thereby disrupting neuromuscular transmission, and leading to flaccid muscle paresis. Injection of toxin into the internal anal sphincter is a new, minimally invasive, effective method of treating children with hypertonicity / achalasia of the sphincter, pelvic muscle dyssynergia, stool retention, secondary fecal incontinence from rectal overflow. The effect of A-type botulinum toxin on smooth muscles of hollow organs has not been yet studied.Objective. To analyze the effect of A-type botulinum toxin on the tone of the smooth muscles of the colon in the experiment.Material and methods. The scientists examined 15 laboratory Sprague Dawley rats. The effect of A-type botulinum toxin on the tone of the smooth muscles of the large intestine was assessed by measuring the stress of the intestinal wall and intraluminal pressure.Results. The scientists revealed a decrease in pressure in the rectum on the 10th day after the injection of A-type botulinum toxin into the segment of the descending colon. The indices of the intestinal wall tension did not differ before the administration of A-type botulinum toxin, as well as in 10 and 20 minutes. The tension in the administration area of A-type botulinum toxin decreased by 81% on the 10th day after injection. There was an indirect decrease in smooth muscle tone in the segments of the colon above and below the injection by 49 and 80%, respectively.Conclusion. The decrease in rectal pressure on the 10th day after the administration of A-type botulinum toxin directly depends upon the decrease in the biovoltage of the overlying sections. Further basic research is needed to assess the effect of the toxin on non-targeted smooth muscle.
Publisher
The National Academy of Pediatric Science and Innovation
Subject
Pediatrics, Perinatology and Child Health
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