Simultaneous measurements of X-ray diffraction (XRD) and differential scanning calorimetry (DSC) data under controlled humidity condition: Instrumentation and application to studies on hydration, dehydration, and rehydration processes of pharmaceutical compounds

Abstract

An instrument for the simultaneous measurement of X-ray powder diffraction (XRD) data and differential scanning calorimetry (DSC) data under a controlled humidity condition has been developed in order to achieve a design concept of reliable and simple in operation. Examples of the application to studies on hydration, dehydration, and rehydration processes of pharmaceutical compounds under various humidity conditions are presented. The usefulness of the present XRD-DSC system will be demonstrated.