Affiliation:
1. Laboratory of Auditory Neurophysiology, KU Leuven , Leuven B-3000, Belgium
Abstract
Counts of spike coincidences provide a powerful means to compare responses to different stimuli or of different neurons, particularly regarding temporal factors. A drawback is that these methods do not provide an absolute measure of latency, i.e., the temporal interval between stimulus features and response. It is desirable to have such a measure within the analysis framework of coincidence counting. Single neuron responses were obtained, from 130 fibers in several tracts (auditory nerve, trapezoid body, lateral lemniscus), to a broadband noise and its polarity-inverted version. The spike trains in response to these stimuli are the “forward noise” responses. The same stimuli were also played time-reversed. The resulting spike trains were then again time-reversed: These are the “reverse-noise” responses. The forward and reverse responses were then analyzed with the coincidence count methods we have introduced earlier. Correlograms between forward- and reverse-noise responses show maxima at values consistent with latencies measured with other methods; the pattern of latencies with characteristic frequency, sound pressure level, and recording location was also consistent. At low characteristic frequencies, correlograms were well-predicted by reverse-correlation functions. We conclude that reverse noise provides an easy and reliable means to estimate latency of auditory nerve and brainstem neurons.
Funder
Fonds Wetenschappelijk Onderzoek
Publisher
Acoustical Society of America (ASA)
Subject
Acoustics and Ultrasonics,Arts and Humanities (miscellaneous)
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献