Affiliation:
1. Eaton-Peabody Laboratories, Massachusetts Eye and Ear and Department of Otolaryngology —Head and Neck Surgery, Harvard Medical School , Boston, Massachussetts 02114, USA viacheslav.vasilkov@meei.harvard.edu ; charles_liberman@meei.harvard.edu ; stephane_maison@meei.harvard.edu
Abstract
In search of biomarkers for cochlear neural degeneration (CND) in electrocochleography from humans with normal thresholds, we high-pass and low-pass filtered the responses to separate contributions of auditory-nerve action potentials (N1) from hair-cell summating potentials (SP). The new N1 measure is better correlated with performance on difficult word-recognition tasks used as a proxy for CND. Furthermore, the paradoxical correlation between larger SPs and worse word scores, observed with classic electrocochleographic analysis, disappears with the new metric. Classic SP is simultaneous with and opposite in phase to an early neural contribution, and filtering separates the sources to eliminate this interference.
Funder
National Institute on Deafness and Other Communication Disorders
Publisher
Acoustical Society of America (ASA)
Subject
Electrical and Electronic Engineering,Atomic and Molecular Physics, and Optics
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献