Abstract
<i>Plasmodium falciparum</i> erythrocyte membrane protein 1 (<i>Pf</i>EMP1), encoded by the polymorphic <i>var</i> multigene family, is a highly polymorphic antigen that plays a crucial role in the pathology of malaria. The contribution of the genetic diversity of <i>var</i> toward the immune escape of <i>P. falciparum</i> has not yet been fully elucidated. This study aimed to characterize the diversity of <i>var</i> repertoires by screening <i>P. falciparum</i> Duffy-binding-like α domain (PfDBLα) among field isolates from central Myanmar. Genetic analysis revealed that the D-H segments of <i>var</i> in Myanmar populations have an extensive polymorphic repertoire, with high numbers of unique sequence types in each individual. However, <i>var</i> genes from the global population, including Myanmar, shared close genetic lineages regardless of their geographic origins, indicating that they have not undergone rapid evolutionary changes.
Funder
National Research Foundation of Korea
Ministry of Science, ICT and Future Planning
Publisher
Korean Society for Parasitology
Subject
Infectious Diseases,Parasitology
Cited by
1 articles.
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