Bridging the gap: Spinal cord fusion as a treatment of chronic spinal cord injury

Author:

Ren Xiaoping123,Kim C-Yoon4,Canavero Sergio5

Affiliation:

1. Hand and Microsurgery Center, Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin, China

2. State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Nangang, Harbin, China

3. Heilongjiang Medical Science Institute, Harbin Medical University, Nangang, Harbin, China

4. Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul, Korea

5. HEAVEN-GEMINI International Collaborative Group, Turin, Italy

Abstract

Despite decades of animal experimentation, human translation with cell grafts, conduits, and other strategies has failed to cure patients with chronic spinal cord injury (SCI). Recent data show that motor deficits due to spinal cord transection in animal models can be reversed by local application of fusogens, such as Polyethylene glycol (PEG). Results proved superior at short term over all other treatments deployed in animal studies, opening the way to human trials. In particular, removal of the injured spinal cord segment followed by PEG fusion of the two ends along with vertebral osteotomy to shorten the spine holds the promise for a cure in many cases.

Publisher

Scientific Scholar

Subject

Clinical Neurology,Surgery

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