An Unusual Glomerulopathy with Subepithelial Deposits Having Microspherular Structures Following COVID-19 Vaccine-Reference-Cited by-同舟云学术

An Unusual Glomerulopathy with Subepithelial Deposits Having Microspherular Structures Following COVID-19 Vaccine

Published:2024-07-01 Issue: Volume:0 Page:1-3
ISSN:1998-3662
Container-title:Indian Journal of Nephrology
language:en
Short-container-title:IJN

Author:

Mir Tajamul Hussain¹,Latief Muzamil²,Sharma Alok³,Jabeen Bushra⁴,Abbas Farhat⁵

Affiliation:

1. Department of Nephrology. Government Medical College Associated Superspecialty Hospital, Srinagar, Jammu Kashmir, India

2. Department of Nephrology, Division Superspecialty Hospital GMC Srinagar, Jammu Kashmir, India

3. Department of Renal Pathology & Electron Microscopy, Dr. Lal PathLabs National Reference Laboratory, New Delhi, India

4. Department of Radiology, Government Medical College Srinagar, Jammu Kashmir, India

5. Department of Pathology, Government Medical College Srinagar, Jammu Kashmir, India

Abstract

We report an unusual glomerulopathy with nephrotic syndrome and acute kidney injury almost two weeks after the second injection of SARS CoV-2 vaccine covishield, ChAdOx1-nCoV-19 in a 75-year-old healthy man. Kidney biopsy revealed segmental stage 1 membranous glomerulopathy and collapsing focal segmental glomerulosclerosis pattern with immune complexes on IF. Electron microscopy (EM) revealed aggregates of spherular microparticles along glomerular capillary walls. After starting him on steroids, his kidney functions gradually improved with significantly reduced proteinuria. Our patient seems to be the only reported SARS CoV-2 vaccine-induced early membranous nephropathy showing a collapsing focal segmental glomerulosclerosis pattern and immune complexes on IF with subepithelial deposits consisting of microspherular particles on EM.

Publisher

Scientific Scholar

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