Unusual presentation of an Epstein barr virus-negative extranodal natural killer/T cell lymphoma: A diagnostic dilemma

Author:

Kilaru Sindhu1,Panda Soumya Surath1,Mishra Sourav2,Mohapatra Debahuti3,Kolluri Spoorthy1,Baisakh Manas3,Moharana Lalatendu1,Devaraj Suma1,Das Hemlata3

Affiliation:

1. Department of Medical Oncology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India,

2. Department of Medical Oncology, Apollo Hospital, Bhubaneswar, Odisha, India,

3. Department of Pathology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India,

Abstract

Extra-nodal Natural killer/T cell lymphoma (ENKTL) is a well-defined and highly aggressive form of NonHodgkin’s lymphoma with a scarcity of cases reported in literature. The most common primary site of involvement is the nasal cavity followed by skin and the gastrointestinal tract (GIT). Cutaneous involvement is a rarity. More than 95% of cases are usually in association with Epstein Barr Virus (EBV) infection. EBV negative ENKTL can be similar in clinical, pathological, and prognostic characteristics with EBV positive ENKTL. This malignancy is usually characterized by its poor prognosis irrespective of clinical stage and therapy. We describe here, a 58-year-old man presenting with multiple nodular lesions over legs and trunk, had an ileal perforation later, and was diagnosed as ENKTL on the ileal biopsy specimen. This case is being reported in view of the fulminant clinical course of the disease, simultaneous involvement of the GIT and skin without nasal or midline involvement, the usefulness of immunohistochemistry in arriving at a diagnosis, and EBV negativity which is quite rare in the Asian population.

Publisher

Scientific Scholar

Subject

General Medicine

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