Chitosan/PEG-mediated spinal cord fusion after complete dorsal transection in rabbits – functional results at 30 days-Reference-Cited by-同舟云学术

Chitosan/PEG-mediated spinal cord fusion after complete dorsal transection in rabbits – functional results at 30 days

Published:2023-12-13 Issue: Volume:14 Page:423
ISSN:2152-7806
Container-title:Surgical Neurology International
language:en
Short-container-title:

Author:

Lebenstein-Gumovski Michael¹,Rasueva Tanzila²,Zharchenko Alexander³,Bashahanov Robert³,Kovalev Dmitry A.⁴,Zhirov Andrey⁴,Shatokhin Anton¹,Grin Andrey²

Affiliation:

1. Department of Neurology and Neurosurgery, Stavropol State Medical University, Stavropol, Russian Federation

2. Clinic of Neurosurgery, N. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department, Moscow, Russian Federation

3. Department of General Medicine, Stavropol State Medical University, Stavropol, Russian Federation

4. Laboratory of Biochemistry, Stavropol Research Institute for Plague Control, Stavropol, Russian Federation.

Abstract

Background: The aim was to study functional recovery in experimental animals (rabbits) with transected spinal cords treated with a combination of photo-cross-linked chitosan in a homogeneous mixture with polyethylene glycol (PEG-chitosan). Methods: 20 rabbits (n = 10 experimental and n = 10 controls) were submitted to complete spinal cord transection at T9. The experimental group received an intraoperative injection of PEG-chitosan. Neurological recovery was assessed using the modified Basso, Beattie, and Bresnahan scale. Results: In the experimental group, partial recovery of movements, sensory function, and sphincter control were all observed by postoperative day 30. Paraplegia and anesthesia persisted in the control group; 4 controls died versus none in the test group. Conclusion: PEG-chitosan is a candidate for neurological restoration after spinal paralysis.

Publisher

Scientific Scholar

Subject

Neurology (clinical),Surgery

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