A monocentric, single-group study to evaluate the effect of pramoxine containing moisturizing cream in participants with pruritis

Abstract

Objectives: The objective of the study was to evaluate the effectiveness of a blend of moisturising cream with anesthetic agent for the treatment of pruiritis. Materials and Methods: A prospective, single-group, and single-center trial to assess the efficacy and acceptability of moisturizing cream in patients with pruritis was carried out. The study included patients who were diagnosed at least once at one site with chronic pruritis with dryness, chronic itch for more than 6 weeks (H/o Itch every day), and itch score on visual analogue scale (VAS) (mild-to-moderate – equal to or <7 on VAS). P = 0.05 or lower indicated statistical significance. Results: A total of 32 patients were included in the study. Following the application of moisturizing cream, the percentage reduction in pruritis severity ranged from 26.3% at 3 min to 66.9% at 8 h. The mean itch score at baseline was 5.922 ± 0.908, while at 3 min, it was 4.366 ± 2.034. At 8-h post-application, it was 2.781 ± 1.460. The P-value for all the itch scores after application of the moisturizing cream right from 3-min to 8-h post-application was 0.001 which is highly significant. Conclusion: In patients with chronic pruritis, moisturizing cream with pramoxine as the topical local anesthetic significantly decreased the mean itch score. The onset of action began as soon as 3 min after application, and over the course of 8 h, a noticeable decrease in the severity of pruritis was seen in this study. The cream was well tolerated with no adverse effects in this study.