Serpentine supravenous hyperpigmentation – A rare cutaneous manifestation in non-neoplastic conditions

Abstract

Serpentine erythematous or hyperpigmented streaks along with the superficial venous network usually occur as a distinctive eruption after infusion of several chemotherapeutic agents. This morphological pattern has been described under various terms such as “persistent supravenous erythematous eruption,” “persistent serpentine supravenous hyperpigmented eruption,” or “persistent serpentine supravenous hyperpigmentation (SSH). We describe four patients with no history of malignancy or treatment for malignancy who developed SSH.