Outcomes in pituitary adenoma causing acromegaly following endoscopic endonasal transsphenoidal surgery

Author:

Chhabra Rajesh1,Kumar Ashwani2,Virk R. S.3,Dutta Pinaki4,Ahuja Chirag5,Mohanty Manju1,Dhandapani Sivashanmugam1

Affiliation:

1. Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India

2. Department of Neurosurgery, Government Medical College and Hospital, Chandigarh, India

3. Department of Otorhinolaryngology, Post Graduate Institute of Medical Education and Research, Chandigarh, India,

4. Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India,

5. Department of Neuroradiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India,

Abstract

Objectives: The objectives of the study were to study the analysis of outcomes after endoscopic endonasal transsphenoidal surgery (EETSS) in acromegaly in terms of surgical complications, clinical improvement, endocrinological remission, achievement of prognostically critical growth hormone (GH) level, and requirement of additional treatment. Materials and Methods: The study included 28 acromegaly patients, who underwent EETSS. A 2010 consensus criterion was used for defining remission. Assessment of prognostically critical GH level (random value <2.5 ng/ml), the extent of resection and additional treatment, was done at post-operative week (POW) 12. Results: All adenomas were macroadenomas; with a mean volume of 16.34 cm3 (range, 0.4–99 cm3). Most adenomas had high-grade extensions. Most common suprasellar, infrasellar, anterior, and posterior extension grades were 3 (n = 13), 1 (n = 16), 1 (n = 14), and 0 (n = 20), respectively. Knosp Grade 3 was common on both sides (right, n = 9 and left, n = 8). One patient had already been operated on with EETSS, 1.5 years back from current surgery. Sixteen patients were on hormonal support, preoperatively. Four patients died during follow-up. Post-operative common complications were diabetes insipidus (DI, n = 18), cerebrospinal fluid rhinorrhea (n = 10), surgical site hematoma (n = 3), meningitis (n = 3), hydrocephalus (n = 2), and syndrome of inappropriate antidiuretic hormone (n = 1). The mean hospital stay was 11.62 days and 12.17 months were the mean follow-up period. At 12 POW, no improvement was seen in body enlargement and visual complaints, but all other complaints improved significantly except perspiration. Adenomas were decreased in all extensions except posterior and mean adenoma volume was reduced from 16.34 cm3 to 2.92 cm3 after surgery. Sub-total resection (STR, n = 10), near-total resection (NTR, n = 7), gross-total resection (GTR, n = 5), and partial resection (PR, n = 2) were achieved. Endocrinological remission and prognostically critical GH levels were attained in 29.17% (n = 7) and 66.67% (n = 16), respectively. NTR, GTR, STR, and PR were associated with 57.14%, 40%, 10%, and 0% endocrinological remission, respectively. Additional treatment was required in a total of 17 patients, three in GTR, nine in STR, three in NTR, and two in PR. Ten were treated with Gamma Knife radiosurgery along with medical treatment and seven with medical treatment alone. Conclusion: A successful EETSS can reduce adenoma volume to achieve clinical improvement, endocrinologic remission, and prognostically critical GH level with some complications related to surgery. Pre-operative larger volume and higher extension grades affect these outcomes adversely.

Publisher

Scientific Scholar

Subject

Neurology (clinical),General Neuroscience

Reference37 articles.

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3. Rapid regression of pituitary prolactinomas during bromocriptine treatment;Thorner;J Clin Endocrinol Metab,1980

4. Acromegaly due to secretion of growth hormone by an ectopic pancreatic islet-cell tumor;Melmed;N Engl J Med,1985

5. Pathogenesis of pituitary tumors;Melmed;Nat Rev Endocrinol,2011

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