Brain metastasis from a thoracic myxofibrosarcoma: A case report and literature review

Author:

Ferreira Neto Otávio da Cunha1,Bezerra Roberto Borges2,Silva Rhuann Pontes dos Santos1,Silva Melissa Helena Rodrigues1,de Alencar Neto Joaquim Fechine3,Lopes Arthur José Maia4

Affiliation:

1. Department of Medicine, Catholic University of Pernambuco, Recife, Brazil

2. Department of Oncology, Hospital Memorial São José, Recife, Brazil

3. Department of Medicine, Unifacisa University Center, Campina Grande, Brazil

4. Department of Neurosurgery, Real Hospital Português, Recife, Brazil.

Abstract

Background: Myxofibrosarcoma (MFS) is a type of sarcoma that mainly affects elderly people; it represents only 5% of all sarcomas and shows no line of differentiation. Intracranial MFS is a rare condition. At present, limited data exist regarding brain metastasis from MFS. This article reports a case of MFS and reviews the literature regarding MFS metastasis. Case Description: We report a case of brain metastasis from chest wall MFS. The patient was diagnosed with an anterior thoracic MFS and underwent surgery and radiotherapy. One year later, he noticed a tumor on his left shoulder, and more than 1 year thereafter, bilateral lung metastasis was observed. Twelve months after lung metastasis, he presented to the emergency department and underwent contrast-enhanced magnetic resonance imaging, which demonstrated a left frontal tumor suggestive of brain metastasis. Since the main hypothesis was a sarcoma metastasis at the location close to the left motor area, and the patient had a good Karnofsky performance scale, the patient underwent neuronavigation-guided surgery. After surgery, the patient developed Grade III hemiparesis and aphasia. Brain tumor histopathology confirmed a malignant neoplasm with osteosarcomatous differentiation and metastasis from MFS. Conclusion: We report a rare case of MFS metastasis. To the best of our knowledge, this is the eighth case of intracerebral metastasis from MFS.

Publisher

Scientific Scholar

Subject

Neurology (clinical),Surgery

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3. Primary cardiac high-grade myxofibrosarcoma presenting with multiple brain metastases: A case report;Badaloni;Cureus,2017

4. Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes;Chan;Rare Tumors,2020

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