Affiliation:
1. Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan,
Abstract
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder. Recent clinical and basic research has demonstrated that AD is an immune-mediated disease involving multiple inflammatory pathways and is considered a T helper (TH)2-centered disease involving a common TH22 component. Recently, some reports demonstrated that Asian patients with AD are more likely to present with clearly demarcated lesions with prominent scaling and lichenification and may exhibit distinct immune and barrier features compared with European American patients with AD. Besides TH2 activation, patients of Asian descent (Japanese, Korean, and Chinese) with AD had strong TH17 activation, overlapping clinically and molecularly with some hallmarks of psoriasis.