Caspase recruitment domain-containing proteins and dermatoses

Abstract

The caspase recruitment domain (CARD) is a protein interaction module that comes under the death domain superfamily. CARD mediates important cellular signaling events. Abnormalities in these cellular signaling events play a role in the pathogenesis of malignancies and immune disorders. The significance of CARD in dermatological diseases is less discussed. Mutations affecting CARD-containing proteins are reported to play a pathogenic role in certain patients with dermatoses such as psoriasis, pityriasis rubra pilaris, atopic dermatitis, and fungal infections. These underlying mutations are suggested to have therapeutic implications in various dermatoses, though more information is needed regarding this. This review discusses the association between dermatoses and mutations involving CARD-containing proteins.