Cholesterol Crystals in Odontogenic Cysts: An In-Depth Narrative of Pathogenesis

Author:

Sachdev Sanpreet Singh1,Singh Praveen2,Chettiankandy Tabita Joy1,Trimukhe Akshay1,Sachdev Jyotsna Batra3,Richhawal Anil2

Affiliation:

1. Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Mumbai, Maharashtra, India

2. Department of Conservative Dentistry and Endodontics, Yerala Medical Trust Dental College and Hospital, Navi Mumbai, Maharashtra, India

3. Sau Mathurabai Thorat Dental College and Hospital, Sangamner, Maharashtra, India,

Abstract

Cholesterol crystals (CCs) are a relatively common finding in infected odontogenic cysts occurring in about 60% of the cases. Histopathologically, these appear as longitudinal cleft-like spaces or may appear as a collection in cholesterol granulomata. The occurrence of CCs in odontogenic cysts is closely associated with the pathophysiology of the lesions. Despite being fairly common, not much is known about the sources of cholesterol, the mechanism of formation of these clefts, their pathogenesis, and their clinical implications. The present article focuses on describing CCs with respect to their contents, pathogenesis, and clinical implications. Our review describes the mechanism of the formation of CCs in a detailed manner along with a pictorial depiction of the cascade of events involved in the process. The formation of cholesterol granulomata is a cumulative effect of the breakdown of erythrocytes and leukocytes, intramural hemorrhage, decreased blood supply and lymphatic drainage, hypoxic conditions, increased vascular permeability, accumulation and rupture of lipid-laden macrophages, and foreign body reaction. It would be of great interest to pathologists to have an in-depth understanding of the pathogenesis, nature, and implications of CCs, which are very common yet enigmatic entities.

Publisher

Scientific Scholar

Subject

General Medicine

Reference25 articles.

1. On the Causes of Persistent Apical Periodontitis: A Review;Nair;Int Endod J,2006

2. Cysts of the Oral and Maxillofacial Regions;Shear,2008

3. Some Observations on the Fluids of Odontogenic Cysts;Browne;J Oral Pathol,1976

4. Histochemical Studies on Cholesterol Formation in Odontogenic Cysts and Granulomas;Arwill;Scand J Dent Res,1973

5. Cholesterol Granuloma of the Jaws: Report of Two Cases;Alkan;J Pak Med Assoc,2014

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3