Cerebrospinal fluid protein concentration in patients with lumbar spinal stenosis

Author:

Yamahata Hitoshi1,Ijiri Kosei2,Tanabe Fumito2,Murasumi Kyoichi2,Nagano Yushi1,Makino Ryutaro1,Higa Nayuta1,Hanaya Ryosuke1

Affiliation:

1. Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kirishima, Kagoshima, Japan

2. Department of Orthopaedics, Kirishima Orthopaedics, Kirishima, Kagoshima, Japan

Abstract

Background: In this study, we examined the impact and degree of lumbar stenosis on cerebrospinal fluid (CSF) protein concentration. Methods: In this retrospective study, we analyzed protein concentrations in CSF samples of 61 patients with lumbar spinal stenosis (LSS) obtained during pre-operative myelography. Patients were divided into two groups: those showing no block to contrast (Group A) versus those showing medium block to contrast below the lumbar puncture level (Group B). Results: The CSF protein concentration in Group B (104.3 ± 59 g/dL) patients with medium block was significantly greater than that in Group A (65.1 ± 33 g/dL) patients without medium block. Conclusion: A higher average CSF protein concentration was seen in Group B patients with significant lumbar stenosis versus Group A patients without significant lumbar stenosis. Theoretically, damage to the cauda equina in patients with LSS may cause these elevated CSF protein levels.

Publisher

Scientific Scholar

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