“Leopard skin” sign: Magnetic resonance imaging appearance of Lhermitte-Duclos disease with histopathologic correlation

Abstract

Dysplastic cerebellar gangliocytoma or Lhermitte-Duclos disease (LDD) is a rare hamartomatous malformation of cerebellum that can occur in isolation or as a component of Cowden syndrome. Although uncommon, the characteristic clinical symptoms and magnetic resonance imaging (MRI) features are highly suggestive of the condition and histopathological features confirm the diagnosis. We report a case of LDD, presenting with “Leopard skin” appearance of the lesion on MRI with a brief review of imaging, clinical, and histopathological features.