C-Reactive Protein: Significance of a Non-Specific Biomarker: A Review

Abstract

C-reactive protein (CRP) is a non-specific acute phase reactant that increases in response to infection or inflammation. Higher levels suggest a more severe infection and have been used to predict the severity of COVID-19 disease. CRP, an acute phase protein, is one of several downstream indicators of inflammation. CRP improves cell-mediated immunity by increasing phagocytosis, hastening chemotaxis, and activating platelets. Here, in this review, we will discuss more about historical background, pathophysiology involved, normal ranges and interpretation of raised levels and significance of CRP in various pathologies. This will further enhance our knowledge related to clinical significance of CRP in day-to-day practice.