Prostate cancer in India: Current perspectives and the way forward

Author:

R. Bhargavi1,Khilwani Barkha2,Kour Bhumandeep3,Shukla Nidhi4,Aradhya Rajaguru1,Sharma Devendra5,Vijayvargiya Maneesh6,Ansari Abdul S.2,Sugunakar V.7,Mathur Praveen8,Mishra Ashwani9,Ramaswamy Gopalakrishna10,Sadasukhi Nripesh11,Valadi Jayaraman K.12,Medicherla Krishna Mohan4,Kumar Geetha1,Ecker Rupert C.13,Bissa Bhawana14,Sadasukhi T. C.11,Suravajhala Renuka1,Mishra Nandita1,Mathiessen Rune15,Johri Pranav16,Batra Jyotsna17,Nair Bipin1,Singh Keshav K.18,Suravajhala Prashanth N.1,Lohiya Nirmal Kumar2

Affiliation:

1. Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, Kerala, India

2. Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, Rajasthan, India

3. Department of Biotechnology, Lovely Professional University, Phagwara, Punjab, India

4. Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Jaipur, Rajasthan, India

5. Department of Urology, CK Birla Hospitals, Jaipur, Rajasthan, India

6. Department of Oncopathology, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India

7. Department of Medicine, MNR Foundation for Research and Innovation, MNR Medical College and Hospital, Hyderabad, Telangana, India

8. Department of Pediatric Surgery, SMS Medical College and Hospital, Jaipur, Rajasthan, India

9. Department of Biotechnology, DNA Xperts, Noida, Uttar Pradesh, India

10. Theracues, Theracues Innovations Private Limited, Bengaluru, Karnataka, India

11. Department of Urology, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India

12. Department of Computer Science, FLAME University, Pune, Maharashtra, India,

13. TissueGnostics, Vienna, Austria,

14. Department of Biochemistry, Central University of Rajasthan, Ajmer-Kishangarh, Rajasthan, India,

15. Department of Experimental Biology, NOVA, Lisbon, Portugal,

16. Phage Therapy, Vitalis Phage Therapy, Delhi, India,

17. Translational Research Institute, Queensland University of Technology, Brisbane, Australia,

18. Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States,

Abstract

Prostate cancer (PCa) is one of the burgeoning cancers worldwide. Of late, the number of cases in the Indian subcontinent has been doubling and the incidence as per the population-based cancer registries (PBCR) has increased at an alarming rate. In assessing the trends of PCa, there needs a statistical framework on incidence, comparing PBCRs vis-a-vis with hospital-based cancer registries not only to that of cohorts from India but also to that of West and other consortia. Our erstwhile pilot study on inferring whole-exome sequencing variants has yielded distinct polymorphisms in the Indian phenotype of PCa. There are impending challenges and gray areas that we discuss in this review in lieu of PCa pathogenesis and therapeutics.

Publisher

Scientific Scholar

Subject

Automotive Engineering

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