Host Cell Regulation of Induction of Epstein-Barr Virus-Reference-Cited by-同舟云学术

Host Cell Regulation of Induction of Epstein-Barr Virus

Published:1974-07 Issue:1 Volume:14 Page:174-176
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Glaser Ronald¹,Nonoyama Meihan²

Affiliation:

1. Department of Microbiology, College of Medicine, The Milton S. Hershey Medical Center of The Pennsylvania State University, Hershey, Pennsylvania 17033

2. Department of Microbiology, Rush-Presbyterian St. Luke's and University of Illinois Medical Center, Chicago, Illinois 60612

Abstract

When Epstein-Barr virus (EBV) negative cells (Raji) were treated with iododeoxyuridine, only the early antigen (EA) component was induced. There was no significant increase in EBV DNA and no virus particles were observed. Somatic-cell hybrids were prepared from the fusion of Raji and D98 cells (D98/Raji). When these cells were treated with iododeoxyuridine, early antigen EBV DNA, and virus particles were synthesized. These data suggest cellular control over the expression of the EBV genome.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.14.1.174-176.1974

Reference7 articles.

1. Epstein-Barr virusassociated antigens activated in human cells by 5-bromodeoxyuridine;Gerber P.;Proc. Soc. Exp. Biol. Med.,1972

2. Hybridization of Burkitt Iymphoblastoid cells;Glaser R.;Science,1972

3. Rescue of Epstein-Barr virus from somatic cell hybrids of Burkitt Iymphoblastoid cells;Glaser R.;J. Virol.,1972

4. Synthesis of Epstein-Barr virus antigens and DNA in activated Burkitt somatic cell hybrids;Glaser R.;Virology,1973

5. Incidence of EB virus-containing cells in primary and secondary clones of several Burkitt Iymphoma cell lines;Mauer B. A.;Cancer Res.,1970

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