Affiliation:
1. Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin 53706
Abstract
ABSTRACT
The YjgF/YER057c/UK114 family of proteins is conserved across the three domains of life, yet no biochemical function has been clearly defined for any member of this family. In
Salmonella enterica
, a deletion of
yjgF
results in a requirement for isoleucine when the mutant strain is grown in glucose-serine or pyruvate medium. Feedback inhibition of IlvA is required for the curative effect of isoleucine on glucose-serine medium. On pyruvate medium,
yjgF
mutants are unable to synthesize enough isoleucine for growth. From this study, we conclude that the isoleucine requirement of a
yjgF
mutant on pyruvate is a consequence of the decreased transaminase B (IlvE) activity that has previously been characterized in these mutants.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
45 articles.
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