Affiliation:
1. The Chanock Centre for Virology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
Abstract
γ-Thiochromanone-4-thiosemicarbazone (TCT) inhibits the growth of vaccinia virus in BSCl cells by interfering with viral maturation. A mutant of the virus (TCT
R
) which is resistant to this drug was isolated. This mutant also exhibits resistance to another thiosemicarbazone related compound, isatin β-thiosemicarbazone (IBT). There is a good correlation between the cross-resistance of the two mutants IBT
R
and TCT
R
to TCT and IBT, respectively, and the similar antipoxvirus activity of these two thiosemicarbazone-related compounds.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
7 articles.
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