Persistence of Burkholderia multivorans within the Pulmonary Macrophage in the Murine Lung-Reference-Cited by-同舟云学术

Persistence of Burkholderia multivorans within the Pulmonary Macrophage in the Murine Lung

Published:2004-10 Issue:10 Volume:72 Page:6142-6147
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Chu Karen K.¹,MacDonald Kelly L.²,Davidson Donald J.³,Speert David P.³

Affiliation:

1. Departments of Pathology

2. Microbiology and Immunology

3. Paediatrics, University of British Columbia, Vancouver, British Columbia, Canada

Abstract

ABSTRACT Differences in infection kinetics and host response between Burkholderia multivorans and Burkholderia cenocepacia were demonstrated in a pulmonary infection model in BALB/c mice. B. multivorans persisted in the lung, while B. cenocepacia was cleared. Indirect immunofluorescence and electron microscopy of B. multivorans -infected lungs localized bacteria to macrophages. Clearance of B. cenocepacia was associated with greater interleukin-1β and neutrophil responses than the responses induced by B. multivorans .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.10.6142-6147.2004

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