Oral and Parenteral Therapeutic Options for Outpatient Urinary Infections Caused by Enterobacteriaceae Producing CTX-M Extended-Spectrum β-Lactamases

Author:

Prakash Vidhya1,Lewis James S.2,Herrera Monica L.3,Wickes Brian L.3,Jorgensen James H.234

Affiliation:

1. San Antonio Military Medical Center, Infectious Disease Service, San Antonio, Texas 78234

2. Department of Medicine, The University of Texas Health Science Center and Pharmacy Service, University Hospital, San Antonio, Texas 78229

3. Department of Microbiology and Immunology, The University of Texas Health Science Center, San Antonio, Texas 78229

4. Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas 78229

Abstract

ABSTRACT Effective therapeutic options are needed for community-onset urinary tract infections due to Escherichia coli strains that produce CTX-M extended-spectrum β-lactamases. We examined 46 urinary isolates producing CTX-M against several oral or long-acting parenteral antimicrobial agents. Approximately 90% were susceptible to fosfomycin and to a combination of cefdinir plus amoxicillin-clavulanate. All were susceptible to ertapenem.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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