In Vitro Activity of Ceftaroline against Community-Associated Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, and Daptomycin-Nonsusceptible Staphylococcus aureus Isolates

Author:

Saravolatz Louis1,Pawlak Joan1,Johnson Leonard1

Affiliation:

1. St. John Hospital and Medical Center, Detroit, Michigan

Abstract

ABSTRACT This study assessed the in vitro activities of ceftaroline and five comparator agents against a collection of Staphylococcus aureus isolates. Ceftaroline demonstrated potent activity against community-associated methicillin-resistant S. aureus (CA-MRSA) isolates and showed bactericidal activity against vancomycin-intermediate S. aureus (VISA), vancomycin-resistant S. aureus (VRSA), heteroresistant VISA (hVISA), and daptomycin-nonsusceptible S. aureus (DNSSA) isolates. Ceftaroline may represent a bactericidal treatment option for infections caused by these pathogens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference24 articles.

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2. Centers for Disease Control and Prevention. 2005. Community-associated MRSA information for clinicians. Released 3 February 2005. http://www.cdc.gov/ncidod/dhqp/ar_MRSA_ca_clinicians.html#6 . Accessed 16 June 2009.

3. Charles, P. G., P. B. Ward, P. D. Johnson, B. P. Howden, and M. L. Grayson. 2004. Clinical features associated with bacteremia due to heterogeneous vancomycin-intermediate Staphylococcus aureus. Clin. Infect. Dis.38:448-451.

4. Performance standards for antimicrobial susceptibility testing 18th informational supplement M100-S18. 2008

5. Methods for determining bactericidal activity of antimicrobial agents; approved guidelines. 1999

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