Effect of Antibiotics on Chemotaxis of Human Leukocytes

Author:

Forsgren Arne1,Schmeling David1

Affiliation:

1. Department of Clinical Bacteriology, University of Lund, General Hospital, S-214 01 Malmö, Sweden

Abstract

The effect of 20 different antibiotics on chemotaxis by human neutrophils was studied. Human leukocytes incubated with chloramphenicol, rifampin, sodium fusidate, and tetracyclines in vitro showed markedly depressed migration. The mechanisms by which these antibiotics affect leukotaxis are discussed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference33 articles.

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2. Studies on antibody production. VI. Inhibitory effect of chloramphenicol on synthesis ofantibody in tissue culture;Ambrose C. T.;J. Exp. Med.,1963

3. The effect of divalent cation depletion on phagocytosis of staphylococci;Bryant R. E.;Yale J. Biol. Med.,1969

4. Leukocyte mobility. IH. Effect of absence of glucose in the medium: effect ofpresence of deoxyglucose, dinitrophenyl, puromycin, actinomycin D and trypsin on the response to chemotactic substance: effect of segregation of cells from chemotactic substance;Carruthers B. M.;Can. J. Physiol. Pharmacol.,1967

5. pH-partition behavior of tetracyclines;Colazzi J. L.;J. Pharm. Sci.,1969

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