Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy-Reference-Cited by-同舟云学术

Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy

Published:2023-07-18 Issue:7 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chang Yong S.¹,Li Si-Yang¹,Pertinez Henry²,Betoudji Fabrice¹,Lee Jin¹,Rannard Steven P.²^ORCID,Owen Andrew²,Nuermberger Eric L.¹^ORCID,Ammerman Nicole C.¹³^ORCID

Affiliation:

1. Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. Centre of Excellence in Long-Acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom

3. Department of Medical Microbiology and Infectious Diseases, University Medical Center Rotterdam, Erasmus MC, Rotterdam, The Netherlands

Abstract

Administration of tuberculosis preventive therapy (TPT) to individuals with latent tuberculosis infection is an important facet of global tuberculosis control. The use of long-acting injectable (LAI) drug formulations may simplify and shorten regimens for this indication.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Unitaid

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00481-23

Reference40 articles.

1. World Health Organization. 2021. Global tuberculosis report 2021. World Health Organization, Geneva, Switzerland.

2. World Health Organization. 2015. The End TB Strategy. World Health Organization, Geneva, Switzerland.

3. World Health Organization. 2020. WHO operational handbook on tuberculosis. Module 1: prevention: tuberculosis preventive treatment. World Health Organization, Geneva, Switzerland.

4. The cascade of care in diagnosis and treatment of latent tuberculosis infection: a systematic review and meta-analysis

5. Long-acting formulations for the treatment of latent tuberculous infection: opportunities and challenges

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