Molecular basis of antigenic structures of poliovirus: implications for their evolution during morphogenesis-Reference-Cited by-同舟云学术

Molecular basis of antigenic structures of poliovirus: implications for their evolution during morphogenesis

Published:1992-07 Issue:7 Volume:66 Page:4597-4600
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wiegers K¹,Dernick R¹

Affiliation:

1. Heinrich-Pette-Institut für Experimentelle Virologie Universität Hamburg, Germany.

Abstract

Neutralizing monoclonal antibodies against poliovirus type 1 were obtained after conventional immunization or combined in vivo-in vitro immunization. Antibody binding sites were determined by sequence analysis of neutralization-resistant mutants. Site 3 variants had several amino acid substitutions in previously unidentified positions for neutralization resistance. Evidence for a linkage of subsites 3a and 3b is presented. Some site 3b antibodies as defined previously precipitated 14S subunits, although with reduced titers.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.66.7.4597-4600.1992

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