Potentiation of Isoniazid Activity against Mycobacterium tuberculosis by Melatonin-Reference-Cited by-同舟云学术

Potentiation of Isoniazid Activity against Mycobacterium tuberculosis by Melatonin

Published:1999-04 Issue:4 Volume:43 Page:975-977
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wiid Ian¹,Hoal-van Helden Eileen¹,Hon Dinie¹,Lombard Carl²,van Helden Paul¹

Affiliation:

1. MRC Centre For Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch Medical School,1 and

2. Centre for Epidemiological Research in South Africa, MRC,2 Tygerberg 7505, South Africa

Abstract

ABSTRACT The limited number of effective antituberculosis drugs available necessitates optimizing current treatments. We show that melatonin, which is synthesized in the pineal gland, can cause at least a threefold increase in the efficacy of isoniazid. This suggests that tuberculosis chemotherapy can be improved by innate molecules such as melatonin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.4.975

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