Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae-Reference-Cited by-同舟云学术

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae

Published:2002-12 Issue:4 Volume:66 Page:579-591
ISSN:1092-2172
Container-title:Microbiology and Molecular Biology Reviews
language:en
Short-container-title:Microbiol Mol Biol Rev

Author:

Crespo José L.¹,Hall Michael N.¹

Affiliation:

1. Division of Biochemistry, Biozentrum, University of Basel, CH-4056 Basel, Switzerland

Abstract

SUMMARY TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology,Infectious Diseases

Link

https://journals.asm.org/doi/pdf/10.1128/MMBR.66.4.579-591.2002

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