Role for Mycobacterium tuberculosis Membrane Vesicles in Iron Acquisition

Author:

Prados-Rosales Rafael1,Weinrick Brian C.12,Piqué Daniel G.1,Jacobs William R.12,Casadevall Arturo13,Rodriguez G. Marcela4

Affiliation:

1. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

2. Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, USA

3. Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA

4. Public Health Research Institute Center and New Jersey Medical School—Rutgers, The State University of New Jersey, Newark, New Jersey, USA

Abstract

ABSTRACT Mycobacterium tuberculosis releases membrane vesicles packed with molecules that can modulate the immune response. Because environmental conditions often influence the production and content of bacterial vesicles, this study examined M. tuberculosis microvesicles released under iron limitation, a common condition faced by pathogens inside the host. The findings indicate that M. tuberculosis increases microvesicle production in response to iron restriction and that these microvesicles contain mycobactin, which can serve as an iron donor and supports replication of iron-starved mycobacteria. Consequently, the results revealed a role of microvesicles in iron acquisition in M. tuberculosis , which can be critical for survival in the host.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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