Affiliation:
1. Department of Biology, Boston University, Boston, Massachusetts, USA
Abstract
The diversified NF-κB transcription factor family has been extensively characterized in organisms ranging from flies to humans. However, homologs of NF-κB and many upstream signaling components have recently been characterized in basal phyla, including Cnidaria (sea anemones, corals, hydras, and jellyfish), Porifera (sponges), and single-celled protists, including
Capsaspora owczarzaki
and some choanoflagellates. Herein, we review what is known about basal NF-κBs and how that knowledge informs on the evolution and conservation of key sequences and domains in NF-κB, as well as the regulation of NF-κB activity.
Funder
National Science Foundation
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology
Cited by
65 articles.
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