RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression-Reference-Cited by-同舟云学术

RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression

Published:2019-08-15 Issue:16 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Marshall Aren E.¹²,Roes Michael V.¹³,Passos Daniel T.¹²^ORCID,DeWeerd Megan C.¹²,Chaikovsky Andrea C.⁴⁵,Sage Julien⁴⁵,Howlett Christopher J.³,Dick Frederick A.¹⁶²³

Affiliation:

1. London Regional Cancer Program, Lawson Health Research Institute, London, Ontario, Canada

2. Department of Biochemistry, Western University, London, Ontario, Canada

3. Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada

4. Department of Pediatrics, Stanford University, Stanford, California, USA

5. Department of Genetics, Stanford University, Stanford, California, USA

6. Children’s Health Research Institute, Lawson Health Research Institute, London, Ontario, Canada

Abstract

Proliferative control in cancer cells is frequently disrupted by mutations in the retinoblastoma protein (RB) pathway. Intriguingly, RB1 mutations can arise late in tumorigenesis in cancer cells whose RB pathway is already compromised by another mutation. In this study, we present evidence for increased DNA damage and instability in cancer cells with RB pathway defects when RB1 mutations are induced.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Cancer Research Society

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00105-19

Reference61 articles.

1. Hallmarks of Cancer: The Next Generation

2. The RB and p53 pathways in cancer