Author:
Izawa A,Kisaki Y,Irie K,Eda Y,Nakagome T,Komatsu T
Abstract
The chemotherapeutic properties of miloxacin (5,8-dihydro-5-methoxy-8-oxo-2H-1,3-dioxolo-[4,5-g]quinoline-7-carboxylic acid) have been compared with those of oxolinic acid and nalidixic acid. The in vitro activities of miloxacin (minimum inhibitory concentrations) against a variety of gram-negative bacteria, especially Enterobacteriaceae and Haemophilus, were comparable to those of oxolinic acid and 8 to 16 times greater than those of nalidixic acid. Miloxacin was more active than oxolinic acid against some anaerobes and less active against staphylococci. Miloxacin exhibited significant activities when administered orally to mice infected with Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, or Serratia marcescens. Its efficacy was comparable to that of oxolinic acid and two to four times greater than that of nalidixic acid. Miloxacin was less active against a Pseudomonas aeruginosa infection and inactive at the maximum test doses against a Streptococcus pyogenes infection.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference3 articles.
1. Studies on quinoline derivatives and related compounds. 5. Synthesis and antimicrobial ac-D. L; Kasper. 1977. Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters;Agui H.;J. Infect. Dis.,1977
2. Absorption and excretion of miloxacin in seruim, urine, and bile of mice, rats, and dogs;Izawa A.;Antimicrob. Agents Chemother.,1980
3. Turner F. J. S. M. Ringel J. F. Martin P. J. Storino J. M. Daly and B. S. Schwartz. 1968. Oxolinic acid a new synthetic antimicrobial agent. I. In vitro and in vivo activity p. 475-479. Antimicrob. Agents Chemother. 1967.
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献