Diagnostic Accuracy of Stool Xpert MTB/RIF for Detection of Pulmonary Tuberculosis in Children: a Systematic Review and Meta-analysis

Author:

MacLean Emily12ORCID,Sulis Giorgia12,Denkinger Claudia M.234,Johnston James C.256,Pai Madhukar12,Ahmad Khan Faiz127

Affiliation:

1. Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada

2. McGill International TB Centre, McGill University, Montreal, Canada

3. Foundation for Innovative New Diagnostics, Geneva, Switzerland

4. Department of Infectious Diseases, University of Heidelberg, Heidelberg, Germany

5. Division of Respiratory Medicine, University of British Columbia, Vancouver, Canada

6. BC Centre for Disease Control, Vancouver, Canada

7. Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre and Montreal Chest Institute, Montreal, Canada

Abstract

Invasive collection methods are often required to obtain samples for the microbiological evaluation of children with presumptive pulmonary tuberculosis (PTB). Nucleic acid amplification testing of easier-to-collect stool samples could be a noninvasive method of diagnosing PTB.

Funder

Foundation for Innovative New Diagnostics

Fonds de Recherche du Québec - Santé

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference25 articles.

1. World Health Organization. 2018. Global tuberculosis report 2018. World Health Organization, Geneva, Switzerland.

2. A Refined Symptom-Based Approach to Diagnose Pulmonary Tuberculosis in Children

3. World Health Organization. 2013. Policy update. Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF assay for the diagnosis of pulmonary and extrapulmonary TB in adults and children. World Health Organization, Geneva, Switzerland.

4. Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in children: a systematic review and meta-analysis

5. Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children: An Update

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