Mutations in PB1, NP, HA, and NA Contribute to Increased Virus Fitness of H5N2 Highly Pathogenic Avian Influenza Virus Clade 2.3.4.4 in Chickens-Reference-Cited by-同舟云学术

Mutations in PB1, NP, HA, and NA Contribute to Increased Virus Fitness of H5N2 Highly Pathogenic Avian Influenza Virus Clade 2.3.4.4 in Chickens

Published:2021-02-10 Issue:5 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Youk Sung-Su¹^ORCID,Leyson Christina M.¹^ORCID,Seibert Brittany A.²^ORCID,Jadhao Samadhan¹³,Perez Daniel R.²^ORCID,Suarez David L.¹^ORCID,Pantin-Jackwood Mary J.¹^ORCID

Affiliation:

1. Exotic and Emerging Avian Viral Diseases Research Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, Athens, Georgia, USA

2. Department of Population Health, University of Georgia, Poultry Diagnostic and Research Center, Athens, Georgia, USA

3. Department of Pediatrics, School of Medicine, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia, USA

Abstract

H5Nx highly pathogenic avian influenza (HPAI) viruses of the A/goose/Guangdong/1/96 lineage continue to circulate widely, affecting both poultry and wild birds. These viruses continue to change and reassort, which affects their fitness for different avian hosts.

Funder

U.S. Department of Agriculture

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01675-20

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